A young woman’s body is found in the Arizona desert, scorched by the sun. Over 2,500 miles away, a young man worries about his missing sister. An investigation into her death begins, and it will take decades to reveal her name and her killer.

Not long after a jogger discovers a woman’s body off a remote road in Pennsylvania, a family worries when the godmother never shows up to a baptism. A frantic search begins for a missing woman that leads investigators up and down the east coast.

An unidentified woman's body surfaces in the warm waters of the Gulf of Mexico; meanwhile, a woman vanishes from her new home in Florida, then, nearly 30 years later, both tales are untangled to reveal a story of love, loss, life, and death.

In 2005, Pamela Knight vanishes on her son's birthday, and, years later, two men find the remains of a woman buried under an abandoned shed.

After a young woman's body is discovered naked in a Minnesota ditch, investigators embark on a decades-long hunt to identify her; meanwhile, over 1,000 miles away, a despairing family refuses to stop looking for the daughter and sister they love.

A heartbroken woman waits for her daughter to come home for the holidays, but she never does; in another state, investigators find a woman's remains, and these two seemingly unrelated incidents come together as investigators finally catch a break.