Wolf is assigned to a patient that has lost hope that she will receive a life-saving lung transplant in time. Keon confides in a former football friend about a traumatic incident. Naz is assigned as Sinead's assistant.

Grace to is forced to confront her own past trauma when she encounters a patient whose diagnosis proves to be elusive.

Grace mediates between a patient's partner and son while adjusting to the unwanted arrival of the new hospital CEO.

Keon gets hazed by Nurse Molly, then gets off on the wrong foot with a patient in handcuffs. Wolf suddenly finds himself under serious financial pressure and considers taking desperate measures.

When Naz realizes her patient has a more serious condition than anyone realized, Naz forms a special bond with the patient's cousin. An over-exhausted and under-slept Wolf struggles on the job and draws Damien's wrath.

Ashley and Caro explore past relationships. Keon grapples with Molly's attempts to sideline him. Naz tries to balance her emotional connection to a patient with his medical needs. Wolf is forced to leave his comfort zone and care for a newborn baby.

Ashley receives an ultra-religious patient who is willing to put himself at peril to appease God, forcing Ashley to reconsider her own religious past. Naz supports a pregnant patient through the hardest decision of her life.

Keon finds himself supporting his patient's fiancée when a swift recovery has an unexpected side effect. Naz treats a former Olympian whose rare condition requires creative solutions. Wolf helps a frequent flyer with hearing loss.

Under pressure to steal more drugs, Wolf is forced into an ethical dilemma in which he is turned against his patient. While trying to protect her patient before a major surgery, Ash is forced to confront Sinead about her drinking problems.